The greatest enemy that faces mankind in the twentieth and twenty first century, after World War II, is undoubtedly, the syndrome HIV/AIDS. It is a World War III in that it has mankind of all nations as targets. The predominance however, is in Africa, in view of the prevalence of causal factors of poverty, famine, and general underdevelopment. The worldwide nuisance of the pandemic has engaged the attention and cure by the world body, the United Nations Organisation, and the regional organisation, the African Union, in search for solutions to end or lessen the effect of the pandemic. The attention should equally engage African governments to prioritise their already tight budgets in favour of service delivery on HIV/AIDS. In South Africa, the effects of the pandemic are equally severe. It is estimated that by 2005 6million South Africans could be infected by the pandemic; and average life expectancy is likely to fall from 60 years to 40 years by 1908. Over the next decade, the number of employees lost to AIDS could be the equivalent of 40 percent of the available workforce. The pandemic is proving expensive in terms of rising cost of employee benefits, labour turnover, on staff morale, shortage of skilled labour, and a reduction in GDP growth rates. The above scenario of flashpoints to mankind survival requires the development of concerted and sustainable approach for combat and cure of the pandemic. The advent of popular democracy in South Africa has had an impact on policy formulation for HIV/AIDS pandemic. The nation’s chief executive has explained the cause of the pandemic from a holistic point of view; and, as systems theory would propose, there had been inputs, demands and court reactions. This paper examines the extent of HIV/AIDS impact on the South African populace; outlines the trend of policy formulation interaction among stakeholders, and posits that Government policy on HIV/AIDS is comprehensive; yet awareness among the most vulnerable looks minimal.