In recent years, the resurgence of deadly infectious diseases within and across geo-political boundaries is reconfiguring the contours of global governance and global politics. In the global health context, the menace of disease in an interdependent world propelled by the phenomenon of globalization has immersed all of humanity in a single microbial sea. Both nation-states and non-state actors (NGOs and civil society organizations) agree that inherited models of global health governance are ineffective in the face of the global crisis of HIV/AIDS and its prevalence in Africa. This paper assesses the politics of global governance of HIV/AIDS and argues that existing structures of global governance of the pandemic has relegated Africa to the margins. The paper uses the images of victims and savagery to critique the harp-hazard commitments of the G8 Summit on HIV/AIDS as well as the politics of access to generic drugs at the World Trade Organization. Africans are the victims of global mis-governance of AIDS. Whether this mass killing is intentional or accidental, the world needs humane global health governance to diminish human vulnerability to HIV/AIDS in the “dark-continent”.