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A.I. Akinwande
University of Lagos, Nigeria

 

     

Therapeutic Uses of Momordica charantia
(with R.I. Bakare and O. A. Magbagbeola)

The importance of information dissemination cannot be overemphasized in educating man as to the gifts of nature. Medicinal plants are potential and valuable source for pharmaceutical products due to their inherent constitutes, availability and usefulness in curing diseases in their raw and cooked form. Momordica charantia (MC) called Bitter Melon is a plant whose immense values are yet to be discovered. Analysis of the plant revealed the presence of Saponin, flavonoid, Alkaloid, steroidalglucoside and proteins such as α-and ß-Momorcharin and MAP-30. The root and fruits of MC contained about 12.84% and 70% of ash respectively and the elements present are Silicon, Copper, Lead, Zinc, Sodium and Iron. 0.3% of the total alkaloids from the fruits contain 0.035% Charantin and the Steroidal glucosides of the fruits are mixtures of B-D-glucose-ß-Sitosterol and D-5, 25-Stigmastadiene-ß-ol. 32-35% purgative fixed oil reported in the seed contains Stearic, Oleic, Linoleic and Eleostearic acids. Proteins such as Albumin, Globulin and Glutein-rich in amino acids are present in addition to vitamin B, carotene and α-Aminobutyric acid. Documented properties of MC include antihelmintic, antibacterial, antibiotic, antidiabetic, anti-inflammatory, antitumor, purgative and antioxidant. Bitter Melon has the ability to reduce the blood sugar level in diabetics by enhancing cells uptake of glucose and promote insulin release. It also has the ability to inhibits Guanylate cyclase (GC) an enzyme linked to the pathogenesis and replication of psoriasis and cancer, as well as in secretory diarrhea. The inhibition of GC in secretory diarrhea could go along way in preventing this disease. The ribosome inactivating proteins (α and ß - momorcharin) and MAP-30 from MC are capable of inhibiting the HIV infection and replication in-vitro and could be useful in establishing anti-viral drugs, accessible and affordable to the people in less developed countries.


Africa Conference 2005: African Health and Illness
Convened by Dr. Toyin Falola for the Center for African and African American Studies
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