Every human being has ‘n specific view of the world and his/her place in it. This view has been formed (mainly sub-consciously) by various influences such as religion, culture, sexuality, health status, the media and personal experiences, to name but just a few. A person’s worldview functions - in a sense - as the source for the opinions that he/she holds. In this paper the concept of a worldview will be critically analysed from a philosophical perspective, with specific focus on the dynamic interaction between so-called Western, Eastern and African worldviews in the debate on health care in South Africa. This ongoing debate regarding “Western orthodox medicine”, “Complementary and Alternative Medicine” and “African Traditional Medicine” in South Africa. is a clear indication of the important role that people’s worldviews play in them having different opinions regarding issues of public and personal importance. Against the background of the call for an “African Renaissance” as well as the continent’s struggle with HIV and AIDS, I will argue that a better understanding (interpretation) of the different ways in which people view the world and their place in it can contribute much in this regard. In order to illustrate the practical value of understanding (consciously interpreting) one’s own worldview as well as those of other people, I will apply the philosophical tool of worldview-interpretation not only on the public health care debate, but also on the relationship between patients and health practitioners.