This paper emphasises the need for an understanding of the health/illness continuum in Africa that is grounded in and reflects existential life experiences of African people. Health, illness, healing and witchcraft are seen as important defining components of the African health/illness discourse. The approach to health in Africa has to consider the African world view. In Africa, life is viewed and experienced as one indivisible whole, a single unit in which all components work in unison. There is indeed, no division and/or differentiation between the animate and the inanimate, matter and spirit, the living and the non-living, physical and metaphysical, secular and sacred, body and soul, and so forth. Everything in Africa is believed and experienced to be in relationship, one with another. This emphasises the significance of interdependence. The visible and invisible world, both make sense to the African mind and are vital to human health and its sustenance. Both worlds are equally important to human illness – its genesis, prevention and cure. Africans are indeed, convinced that, it is only in the presence of harmony, balance or tranquillity that health can be a reality. Hence these values must constantly be sought and maintained. Society is understood to be an integrated entity that is not compartmentalised, for instance, into medicine, sociology, law, politics and religion. Life is a service to humanity and in conjunction with society a celebration of victories and/or sacrifices of others (cf. Berinyuu 1988:5). The paper argues that the health/illness discourse in Africa cannot be meaningful if Western intervention strategies are slavishly adhered to without due consideration for the unique situations of African peoples. Both appreciation of the holistic African approach and constructive critique of aspects of its healing practices will be offered. It further proposes an Afro-Christian healing ministry in which God’s omnipotence is central to intervention in health restoration.