The AIDS epidemic in developing countries of the world has aggravated the labor burdens of men and women. Women, in particular, carry a substantial burden of caring for the sick and dying and often become the principal breadwinners in the absence of male household heads. The impact of this care has not been evaluated, quantified, or even recognized in the economy. This paper examines the impact of HIV/AIDS on women in the economy of care within Nigerian households. A survey of households with HIV/AIDS patients were carried out in the state of Lagos with the assistance of NGO members and hospital personnel. A participatory approach was employed to get in touch with the households. Interviews were conducted with randomly selected twenty women to elicit information on how caring for family members infected with HIV/AIDS has impacted their socio-economic activities in the community. The paper discovered that care for HIV/AIDS patients in a family impacts heavily on the women. The findings reflected their changing roles and responsibilities in household and market activities. The women also indicated their difficulty in gaining access to and control of assets and resources. A number of recommendations were made to relieve women in Nigeria from the burden of care. These include promoting a sense of equal responsibility in care-giving among men and women, ensuring equal access to loans and resources, and introducing measures that restore social and economic power balance in the community.