Although there are lots of references to prostitution, especially activities of commercial sex workers, as the main through which HIV/AIDS spreads in Africa, nevertheless, there has not been any critical study to prove this. Yet, unfortunately, the main thrust of most campaign on HIV/AIDS is directed against commercial sex workers, forgetting other unexplored or as yet unknown means through which HIV/AIDS spreads, one of which is economic disenchantment of people in third world countries. Recent studies show that the spread of the pandemic may not necessarily be the result of activities of women of easy virtues, but could be attributable to poverty occasioned by state's failure to guarantee the most basic needs of its people. Clear evidences abound that prostitutes living in brothels and in full time employment would, as a standard rule, insist on the use of condom as a preventive measure against HIV/AIDS, while part-time prostitutes lurking around street-corners, being merely students or artisans, and hawkers wishing to play a fast one to temporarily gain some economic empowerment, lack the 'technical expertise' requisite of the trade and therefore more susceptible to the infection. This and other misconceptions about how the pandemic spreads affect not only our understanding of the dynamics involved in the pandemic, but also on programs and actions aimed at curtailing its spread. Drug use and/as preventive measures dominate institutional programs and policies to fight the pandemic but the continued spiraling of the disease points to inadequacies inherent in these methods, thereby calling for new approaches. While the received doctrines on causes of the spread of the pandemic tilted towards prostitution and unsafe sex habit among people, research is yet to prove why people prostitute. Prostitutes abound in all societies, including developed countries but Africa and Asia feel the scourge of the dreaded disease HIV/AIDS, more, for these continent accounts for about 78% of the worst recorded cases of HIV/AIDS. It therefore follows that if prostitution is a global phenomenon, then the prevalence of the pandemic in Africa cannot be because of prostitution. However, research has shown that prostitutes, especially professional prostitutes practice safe sex more than as previously believed. Aside from transmission through unscreened blood, and birth, sex remains the only remaining ways of transmission. If our understanding of the pandemic is rather hazy from the outset, our most genuine efforts at combating the scourge cannot but be misdirected. This lacuna in our understanding has led to new agitation on how HIV/AIDS spread and how to combat it. As against preventive drug-based solutions, as will be canvassed in the paper, action-oriented policy framework should emphasize tackling endemic problems of poverty, social exclusion, famine that paved way for prostitution, be it part-time or full-time. The paper's major contribution lies in challenging and reconciling existing body of beliefs about prostitution, calling for re-definition of concepts and context, re-designing of policy programs to address causes rather than manifestations, and to, above all, call for a paradigm shift in aids regime from drug-based solutions to socio-economic empowerment.