Everything that is bad, we are made to believe, has its roots in Africa. This is very interesting indeed. But the immediate question, especially to a critical mind, is: what is true knowledge? Accepted that knowledge can be used for different purposes, but science, a true science for that matter, exists because of some globally recognized universal principles held to by the whole body of scientists, irrespective of races and intellectual persuasions. More poignantly, can genuine distinction be made between science and scientist. The question is relevant given the dimension of the background to the research on HIV - AIDS .AIDS, we are again told, originated from Africa. But more seriously: does AIDS actually originate from Africa? This is no doubt likely to be the greatest and mightiest of all the research questions and puzzles of the 21st century scientific research. All said, the ongoing analyses of the origin of AIDS , it seems, are further reinforcement of western imperialism and propaganda of the contemporary globalization processes. One of Africa`s distinguished authorities , and arguably Africa’s foremost political economist, Claude Ake had earlier describe as imperialistic social science research methodology. Can the same be said of the broad field of medical science methodology ? The consequent "politics and history" of AIDS and the accompanying racist interpretation and analysis require further thorough investigation and x - ray. This is the task set for the paper from the context of social history and developmental analysis.