Long before the term “globalization” become a household terminology, the Rockefeller Foundation (RF) had embarked on a global crusade at improving health care, medicine, agriculture, urbanization, and civil society in developing and developed economies. The globalization of better life for the downtrodden and poor nations of the world had been a popular culture at RF offices worldwide. In 1940 four brothers were concerned about West African colonies under British rule and the then allied occupied territory of Togo. This concern soon gave birth to a dynamic, capital and human intensive program called “Rockefeller Brothers West African Fund.” John D. 3rd, Nelson A., Laurence S., Winthrop, and David Rockefeller established the Rockefeller Brothers Fund (RBF). The RBF makes grants to local, national, and international philanthropic organizations that depend on the general public for funds. As a general rule, contributions are made to agencies whose activities reach a large number of people. Before colonial governments began to conceptualize future developments in a post World War II West Africa, these band of brothers embarked on programs that later shaped development in health, economics, urbanization, industries (formal and informal sectors), population studies, agriculture and natural sciences, and education. The RBF's program also includes “technical support for, and in some instances direct operation of, experimental or new undertakings.” For instance, between 1957 and 1962 the Rockefeller Brothers Fund undertook a West Africa Program to provide technical assistance to Togo, Ghana, and Nigeria. An intellectual academic history of this event become an essential task given the fact that signing a treaty of technical partnership was essential in British colonies before independent. RBF technical assistance to these countries was to contract for feasibility studies designed to provide realistic frameworks for economic or industrial development in those nations at their request. We should note however that programs were not limited to government agencies. As in the case of Nigeria, RFB’s Fund provided assistance to “Olatunji Center for African Culture” and “Ojike Medical Center” between 1961 and 1976. Whether this is a response to Soviet Union assistance to Marxist group led by Dr. Otegbeye (Eko Kemist) during the same period is yet to be determined. Needless to say that the spirit had been on since 1925 when the Rockefeller Foundation established a Yellow Fever Commission with a office in Yaba, Lagos. By 1954 the Commission had expanded its activities to cover the whole of West Africa region. With the main office in Lagos, Nigeria became the distribution point for RFB’s programs and studies. Its director, Robert I. Fleming, acted as a liaison between the African governments and groups of American investors and arranged their contracts with governmental personnel. I should stress that the study would be conceptualize within the general role of Rockefeller Foundation’s philanthropic activities such as “medical, health, and population sciences, agriculture and natural sciences, arts, humanities and social sciences, and international relations.” Economic cooperation between the United States and Britain was largely based on Economic Cooperation Act and Mutual Security Act of 1950s. The appeal to “Third Force” such as Rockefeller Foundation, the Ford Foundation, and The British Council was briefly mentioned with a view to an in-depth study in the future. Other than this, scholars have neglected the significant role of non-governmental agencies in colonial dependencies during the terminal colonial period but emphasizing post-colonial activities. The primary motive in this study is to bring into the mainstream, the activities of RBF and present a historical analysis of the period between 1953 and 1977.